Background: The article provides the analysis of death rates in road traffic accidents in Kazakhstan from 2004 to 2010 and explores the use of sanitary aviation.Methods: Data of fatalities caused by road traffic accidents were collected and analysed. Descriptive and analytical methods of epidemiology and biomedical statistics were applied.Results: Totaly 27, 003 people died as a result of road traffic accidents in this period. The death rate for the total population due to road traffic accidents was 25.0±2.10/0000. The death rate for men was (38.3±3.20/0000), which was higher (P<0.05) than that for women (12.6±1. 10/0000). High death rates in the entire male population were identified among men of 30-39 years old, whereas the highest rates for women were attributed to the groups of 50-59 years old and 70-79 years old. In time dynamics, death rates tended to decrease: the total population (Tdec=-2.4%), men (Tdec=-2.3%) and women (Tdec=-1.4%). When researching territorial relevance, the rates were established as low (to 18.30/0000), average (between18.3 and24.00/0000) and high (from 24.00/0000 and above). Thus, the regions with high rates included Akmola region (24.30/0000), Mangistau region (25. 90/0000), Zhambyl region (27.30/0000), Almaty region (29.30/0000) and South Kazakhstan region (32.40/0000).Conclusion: The identified epidemiological characteristics of the population deaths rates from road traffic accidents should be used in integrated and targeted interventions to enhance prevention of injuries in accidents.